A pilot randomized controlled trial in vitamin Dinsufficient older adults found that vitamin D supplementation (50,000 IU/week) increased plasma A?40 levels compared with placebo, with greater changes in participants aged 60 and older. The study suggests vitamin D may raise plasma A?40 and potentially reflect decreased brain A?, though the small sample size limits conclusions.
Psoriasis is a systemic inflammatory skin disorder marked by thick, scaly patches and can include psoriatic arthritis, affecting about 7.4 million US adults. It raises the risk of other inflammatory diseases such as cardiovascular disease, diabetes, metabolic syndrome, and stroke, and is managed with conventional treatments plus integrative approaches like diet, lifestyle changes, and supplements.
Beta-amyloid plaque accumulation can damage the brain but is not sufficient to trigger the conversion of tau or the full neurodegenerative process. A second insultthe conversion of taudriven by signaling events, may be required, implying that therapies targeting both amyloid and tau conversion, and doing so before tau changes occur, could be more effective.
